Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234844 | 0.91 | MTOR (0.40) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234812 | 0.91 | CHEK1 (0.47) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10240006 | 0.90 | MTOR (0.41) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7875541 | 0.82 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234849 | 0.81 | MTOR (0.40) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234809 | 0.81 | CHEK1 (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7883194 | 0.80 | MTOR (0.41) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234807 | 0.79 | CHEK1 (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7884582 | 0.79 | MTOR (0.40) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234819 | 0.78 | CHEK1 (0.47) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |