Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.57 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.57 |
| ▸ | EDNRA | P25101 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267833 | 0.86 | PFKFB3 (0.59) | PFKFB3PFKFB4EDNRAKMT2APOLB | |
| SCHEMBL15063697 | 0.86 | PFKFB3 (0.59) | PFKFB3PFKFB4EDNRAKMT2APOLB | |
| SCHEMBL788371 | 0.82 | KMT2A (0.60) | PFKFB3PFKFB4EDNRAMAPTKMT2A | |
| SCHEMBL787540 | 0.80 | PFKFB3 (0.58) | PFKFB3PFKFB4EDNRAMAPTKMT2A | |
| SCHEMBL788401 | 0.79 | EDNRA (0.53) | PFKFB3PFKFB4EDNRAKMT2APOLB | |
| SCHEMBL788078 | 0.79 | EDNRA (0.53) | PFKFB3PFKFB4EDNRAKMT2APOLB | |
| SCHEMBL788107 | 0.78 | PFKFB3 (0.59) | PFKFB3PFKFB4EDNRAMAPTKMT2A | |
| SCHEMBL788385 | 0.78 | EDNRA (0.52) | PFKFB3PFKFB4EDNRAMAPTKMT2A | |
| SCHEMBL788034 | 0.77 | PFKFB3 (0.63) | PFKFB3PFKFB4EDNRAKMT2APOLB | |
| SCHEMBL787817 | 0.77 | EDNRA (0.54) | PFKFB3PFKFB4EDNRAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | claimed |
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | disclosed |