Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.58 |
| ▸ | KIF5B | P33176 | 4/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | ETV6 | P41212 | 2/20 | 0.58 |
| ▸ | CCDC6 | Q16204 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | FGR | P09769 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | BLK | P51451 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | NPM1 | P06748 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584891 | 0.89 | RET (0.58) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL2679666 | 0.86 | KDR (0.57) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL1022445 | 0.81 | RET (0.49) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL10280314 | 0.77 | KDR (0.45) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL10235075 | 0.77 | CHEK1 (0.63) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL7882706 | 0.76 | CHEK1 (0.66) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL7882475 | 0.76 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1MTOR | |
| SCHEMBL7885824 | 0.76 | MTOR (0.44) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL597238 | 0.74 | CHEK1 (0.52) | RETKIF5BKDRETV6CCDC6 | |
| SCHEMBL10238494 | 0.74 | CHEK1 (0.46) | RETKIF5BKDRETV6CCDC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |