Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.46 |
| ▸ | CDK2 | P24941 | 13/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14232237 | 1.00 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL14231717 | 0.90 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL10239412 | 0.89 | CHEK1 (0.50) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL14232420 | 0.89 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL14231723 | 0.88 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL6891872 | 0.87 | CHEK1 (0.62) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931004 | 0.87 | CHEK1 (0.62) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14232234 | 0.85 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL14232422 | 0.85 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL14231721 | 0.84 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |