SCHEMBL7883143

SCHEMBL7883143

CCC1CCN(Cc2cc(N)n3ncc(-c4cnc5ccccc5c4)c3n2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.40
MEN1 O00255 2/20 0.40
NPC1 O15118 2/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
RAB9A P51151 2/20 0.40
KMT2A Q03164 2/20 0.40
HSD17B10 Q99714 2/20 0.40
TP53 P04637 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.40
GFER P55789 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PIK3CA P42336 6/20 0.38
HSP90AA1 P07900 1/20 0.37
MTOR P42345 4/20 0.37
AKT1 P31749 2/20 0.36
CHEK1 O14757 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6893328 0.88 PIK3CA (0.40) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6893473 0.87 KDM4E (0.42) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL584529 0.85 HSP90AA1 (0.45) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6893056 0.85 KDM4E (0.40) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6894410 0.83 KDM4E (0.41) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6891833 0.83 PIK3CA (0.42) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6892777 0.82 HSP90AA1 (0.44) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6894412 0.77 PIK3CA (0.35) KDM4EMEN1NPC1ALDH1A1MAPT
SCHEMBL6895960 0.76 EGFR (0.38) PIK3CAHSP90AA1MTORAKT1EGFR
SCHEMBL6893755 0.74 JAK1 (0.44) KDM4EMEN1NPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010118207-A1 PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS SCHERING CORPORATION (US) 2010-10-14 WO disclosed