Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.84 |
| ▸ | RXRA | P19793 | 18/20 | 0.84 |
| ▸ | NR1H3 | Q13133 | 18/20 | 0.84 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780318 | 0.94 | NR1H2 (0.86) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL779541 | 0.91 | NR1H2 (1.00) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL19579159 | 0.90 | NR1H2 (0.94) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL30412305 | 0.90 | NR1H2 (1.00) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL779280 | 0.90 | NR1H2 (1.00) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL781718 | 0.88 | NR1H2 (1.00) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL16407940 | 0.88 | NR1H2 (0.77) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL780880 | 0.86 | NR1H2 (1.00) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL21653448 | 0.86 | NR1H2 (0.84) | NR1H2RXRANR1H3NR1I2 | |
| SCHEMBL16407947 | 0.85 | NR1H2 (0.89) | NR1H2RXRANR1H3NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163081-A1 | LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-06-12 | — | — | US | disclosed |
| US-20120071534-A1 | LXR MODULATORS | EXELIXIS, INC. | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163081-A1 | LXR MODULATORS | NR1H3, NR1H2, NR1H4 | NR1H2 2/4885RXRA 10/4885NR1H3 1/4885 |
| US-20120071534-A1 | LXR MODULATORS | NR1H3, NR1H2, NR1H4 | NR1H2 2/4885RXRA 10/4885NR1H3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.