Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 3/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | DDO | Q99489 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.47 |
| ▸ | SETD2 | Q9BYW2 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7873309 | 0.99 | NSD2 (0.49) | NSD2HRH4DAODDOSMYD3 | |
| SCHEMBL7881936 | 0.86 | HRH4 (0.50) | NSD2HRH4SMYD3HSD17B10ALDH1A1 | |
| SCHEMBL7873722 | 0.86 | GRIN2D (0.39) | NSD2HRH4DAODDOKDM4E | |
| Hydrochloric Acid SCHEMBL7885038 | 0.85 | HRH4 (0.49) | NSD2HRH4SMYD3HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7877769 | 0.85 | GRIN2D (0.38) | NSD2HRH4DAODDOKDM4E | |
| SCHEMBL7877623 | 0.85 | HRH4 (0.49) | NSD2HRH4DAOHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7878220 | 0.84 | HRH4 (0.48) | NSD2HRH4DAOHSD17B10ALDH1A1 | |
| SCHEMBL7873932 | 0.83 | HRH4 (0.51) | HRH4KDM4EALDH1A1HPGDGLA | |
| Hydrochloric Acid SCHEMBL7881429 | 0.82 | HRH4 (0.50) | HRH4KDM4EALDH1A1HPGDGLA | |
| SCHEMBL7879692 | 0.81 | APEX1 (0.61) | HRH4KDM4EHSD17B10HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |