Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879202 | 0.95 | PDE9A (0.62) | PDE9APDE1C | |
| SCHEMBL7882623 | 0.86 | PDE9A (0.66) | PDE9APDE1C | |
| SCHEMBL12465416 | 0.86 | PDE9A (0.66) | PDE9APDE1C | |
| SCHEMBL7886916 | 0.85 | PDE9A (0.72) | PDE9APDE1C | |
| SCHEMBL7882239 | 0.83 | PDE9A (0.78) | PDE9APDE1C | |
| SCHEMBL7887043 | 0.83 | PDE9A (0.78) | PDE9APDE1C | |
| SCHEMBL7996231 | 0.83 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL7888333 | 0.83 | PDE9A (0.71) | PDE9APDE1C | |
| SCHEMBL7885825 | 0.83 | PDE9A (0.63) | PDE9APDE1C | |
| SCHEMBL7885787 | 0.82 | PDE9A (1.00) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112437-A1 | 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |