Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.65 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.65 |
| ▸ | CALCRL | Q16602 | 14/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 8/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794645 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3R1 | |
| SCHEMBL10229605 | 0.81 | PIK3CD (0.62) | PIK3CDPIK3R1 | |
| SCHEMBL788883 | 0.81 | PIK3CD (0.62) | PIK3CDPIK3R1 | |
| SCHEMBL787761 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3R1TNKSPARP1 | |
| SCHEMBL788011 | 0.80 | PIK3CD (0.63) | PIK3CDPIK3R1 | |
| SCHEMBL15490647 | 0.80 | PIK3CD (0.63) | PIK3CDPIK3R1 | |
| SCHEMBL788012 | 0.80 | PIK3CD (0.63) | PIK3CDPIK3R1 | |
| SCHEMBL806199 | 0.79 | PIK3CD (0.60) | PIK3CDPIK3R1TNKSTNKS2 | |
| SCHEMBL806202 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3R1 | |
| SCHEMBL787981 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | claimed |
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | claimed |