Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.80 |
| ▸ | MAPT | P10636 | 11/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.80 |
| ▸ | CASP1 | P29466 | 2/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | APP | P05067 | 6/20 | 0.74 |
| ▸ | APAF1 | O14727 | 1/20 | 0.73 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.73 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CASP6 | P55212 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14660048 | 0.94 | ADORA1 (0.82) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL8165810 | 0.90 | MAPT (0.71) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL14659429 | 0.89 | ADORA1 (0.84) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL7885074 | 0.89 | MAPT (1.00) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL8166334 | 0.88 | MAPT (0.94) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL7877338 | 0.88 | MAPT (0.88) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL7886436 | 0.88 | ADORA1 (0.81) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL7886346 | 0.88 | ADORA1 (0.81) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL14659677 | 0.88 | ADORA1 (0.81) | ADORA1MAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL8172553 | 0.87 | ADORA1 (0.79) | ADORA1MAPTKDM4EALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169087-B1 | Modulators of protein tyrosine phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2001-01-02 | — | — | US | claimed |
| US-6169087-B1 | Modulators of protein tyrosine phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2001-01-02 | — | — | US | disclosed |
| EP-1017697-A1 | MODULES OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015529-A1 | MODULES OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 1999-04-01 | — | — | WO | disclosed |