Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.57 |
| ▸ | HTR2C | P28335 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.48 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884900 | 1.00 | CASR (0.57) | CASRHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL7884899 | 1.00 | CASR (0.57) | CASRHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL7886595 | 0.89 | HTR2C (0.49) | CASRHTR2CHTR2AHTR2BFFAR1 | |
| SCHEMBL7886585 | 0.89 | HTR2C (0.49) | CASRHTR2CHTR2AHTR2BFFAR1 | |
| SCHEMBL7886592 | 0.89 | HTR2C (0.49) | CASRHTR2CHTR2AHTR2BFFAR1 | |
| SCHEMBL7884872 | 0.88 | HTR2C (0.54) | CASRHTR2CHTR2AFFAR1 | |
| SCHEMBL8002998 | 0.88 | HTR2C (0.54) | CASRHTR2CHTR2AFFAR1 | |
| SCHEMBL7884869 | 0.88 | HTR2C (0.54) | CASRHTR2CHTR2AFFAR1 | |
| SCHEMBL7879525 | 0.87 | HTR2C (0.52) | CASRHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL7879524 | 0.87 | HTR2C (0.52) | CASRHTR2CHTR2AHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172091-B1 | METABOLIC CALCIUM IMBALANCE AND OSTEOPOROSIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-01-09 | — | — | US | disclosed |
| WO-2000021910-A2 | 1,2-DISUBSTITUTED CYCLOPROPANES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-20 | — | — | WO | disclosed |