Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.63 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7888585 | 0.81 | EGFR (0.61) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL3324098 | 0.78 | EGFR (0.57) | EGFRERBB2BRAFKMT2AAURKB | |
| SCHEMBL7890194 | 0.77 | EGFR (0.60) | EGFRERBB2BRAFERBB4KMT2A | |
| Hydrochloric Acid SCHEMBL7880806 | 0.77 | EGFR (0.56) | EGFRERBB2BRAFKMT2AAURKB | |
| SCHEMBL7890444 | 0.76 | EGFR (0.47) | EGFRERBB2BRAFKDRKMT2A | |
| SCHEMBL8368308 | 0.75 | EGFR (0.49) | EGFRERBB2BRAFERBB4KDR | |
| SCHEMBL6770211 | 0.75 | ERBB2 (0.69) | EGFRERBB2ERBB4KMT2A | |
| SCHEMBL8365522 | 0.73 | EGFR (0.47) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL6979258 | 0.73 | ABCG2 (0.69) | EGFRERBB2ERBB4KDRKMT2A | |
| SCHEMBL2987637 | 0.73 | EGFR (0.73) | EGFRERBB2BRAFKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169091-B1 | TREATMENT OF PSORIASIS, FIBROSIS, ATHEROSCLEROSIS, RESTENOSIS, AUTO-IMMUNE DISEASE, ALLERGY, ASTHMA | GLAXO WELLCOME INC. | 2001-01-02 | — | — | US | disclosed |