Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 18/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885705 | 1.00 | OPRL1 (0.49) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7015691 | 1.00 | OPRL1 (0.49) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7885443 | 0.90 | OPRL1 (0.52) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7883371 | 0.90 | OPRL1 (0.52) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7014225 | 0.90 | SMN1; SMN2 (0.43) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7885754 | 0.90 | OPRL1 (0.52) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7887890 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7878605 | 0.88 | OPRL1 (0.52) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7886394 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 | |
| SCHEMBL7885289 | 0.87 | OPRL1 (0.54) | OPRL1OPRM1OPRK1OPRD1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1113881-C | 8-substituted-1,3,8-triaza-spiro [4,5] decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2003-07-09 | — | — | CN | disclosed |
| EP-0856514-B1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2001-06-13 | — | — | EP | disclosed |
| US-6071925-A | ANTIDEPRESSANTS, ANTICONVULSANTS OR ANTIANXIETY AGENTS, ALSO FOR TREATMENT OF MEMORY LOSS IN ALZHEIMER'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-06-06 | — | — | US | disclosed |
| CN-1191862-A | 8-substituted-1,3,8-triaza-spiro [4,5] decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 1998-09-02 | — | — | CN | disclosed |
| EP-0856514-A1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |