Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 9/20 | 0.66 |
| ▸ | TRPC6 | Q9Y210 | 9/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10087865 | 0.88 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL790044 | 0.82 | TRPC3 (0.71) | TRPC3TRPC6HPGDSMN1; SMN2TRPA1 | |
| SCHEMBL10080531 | 0.81 | TRPC3 (0.58) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL12503735 | 0.81 | TRPC3 (0.48) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL10087866 | 0.80 | TRPC3 (0.48) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL10087863 | 0.79 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL806645 | 0.79 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL806650 | 0.78 | TRPC3 (0.56) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL806647 | 0.76 | TRPC3 (0.54) | TRPC3TRPC6HPGDTRPA1CACNA1C | |
| SCHEMBL12751758 | 0.75 | TRPC3 (0.67) | TRPC3TRPC6NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |