Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.79 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989552 | 1.00 | PDE9A (0.79) | PDE9APDE1CPDE1B | |
| SCHEMBL7886923 | 0.94 | PDE9A (0.76) | PDE9APDE1CPDE1B | |
| SCHEMBL7884917 | 0.91 | PDE9A (0.65) | PDE9APDE1CPDE1B | |
| SCHEMBL7876695 | 0.91 | PDE9A (0.64) | PDE9APDE1CPDE1B | |
| SCHEMBL2528957 | 0.89 | PDE9A (1.00) | PDE9APDE1CPDE1B | |
| SCHEMBL7888328 | 0.88 | PDE9A (0.82) | PDE9APDE1C | |
| SCHEMBL7882627 | 0.88 | PDE9A (0.82) | PDE9APDE1C | |
| SCHEMBL12401082 | 0.88 | PDE9A (0.98) | PDE9APDE1CPDE1B | |
| SCHEMBL7881515 | 0.85 | PDE9A (0.61) | PDE9APDE1CPDE1B | |
| SCHEMBL7880542 | 0.85 | PDE9A (0.61) | PDE9APDE1CPDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112437-A1 | 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |