Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886186 | 0.89 | PDE9A (0.68) | PDE9APDE1C | |
| SCHEMBL7989159 | 0.88 | PDE9A (0.49) | PDE9APDE1C | |
| SCHEMBL7879215 | 0.84 | PDE9A (0.65) | PDE9APDE1C | |
| SCHEMBL7886938 | 0.83 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL7887077 | 0.82 | PDE9A (0.55) | PDE9APDE1C | |
| SCHEMBL7888417 | 0.79 | PDE9A (0.72) | PDE9APDE1C | |
| SCHEMBL12401258 | 0.79 | PDE9A (0.54) | PDE9APDE1C | |
| SCHEMBL7887107 | 0.79 | PDE9A (0.51) | PDE9APDE1C | |
| SCHEMBL7881519 | 0.79 | PDE9A (0.55) | PDE9APDE1C | |
| SCHEMBL7876119 | 0.78 | PDE9A (0.51) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112437-A1 | 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |