Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.47 |
| ▸ | MTOR | P42345 | 20/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755541 | 0.80 | PIK3CA (0.48) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL755349 | 0.74 | PIK3CA (0.42) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL2787446 | 0.72 | PIK3CA (0.45) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL2787076 | 0.67 | PIK3CA (0.48) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL756452 | 0.67 | PIK3CA (0.42) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL753251 | 0.67 | PIK3CA (0.50) | PIK3CAMTORPIK3CB | |
| SCHEMBL16161614 | 0.65 | PIK3CA (0.46) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL2772334 | 0.64 | PIK3CA (0.56) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL752349 | 0.64 | PIK3CA (0.65) | PIK3CAMTORPIK3CB | |
| SCHEMBL11026374 | 0.64 | PIK3CA (0.69) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |