Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330908 | 0.83 | KMT2A (0.49) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL459073 | 0.83 | KDM4E (0.61) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL15256754 | 0.81 | KDM4E (0.59) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL10099065 | 0.80 | MAPT (0.56) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL27816955 | 0.75 | KDM4E (0.56) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL2284354 | 0.74 | KDM4E (0.62) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL16690878 | 0.73 | CCR1 (0.62) | KDM4ETDP1ALDH1A1GAAMAPK1 | |
| SCHEMBL12715707 | 0.72 | CCR1 (0.61) | KDM4EALDH1A1KMT2AMEN1OPRK1 | |
| SCHEMBL10015181 | 0.72 | MAPT (0.41) | KDM4ETDP1ALDH1A1GAAKMT2A | |
| SCHEMBL8966258 | 0.71 | KDM4E (0.69) | KDM4ETDP1ALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222369-B2 | Process for preparing macrocyclic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-17 | — | — | US | disclosed |
| US-8017771-B2 | Process for preparing acyclic HCV protease inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-13 | — | — | US | disclosed |
| US-20090326194-A1 | PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20090124808-A1 | PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-14 | — | — | US | disclosed |
| US-20090124809-A1 | PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326194-A1 | PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS | HCCS, CYP3A43, CYP2F1 | KDM4E 2406/4885TDP1 4836/4885ALDH1A1 1235/4885 |
| US-20090124808-A1 | PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS | PREP, VIP, PEPD | KDM4E 2604/4885TDP1 4215/4885ALDH1A1 1259/4885 |
| US-20090124809-A1 | PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS | PREP, VIP, PEPD | KDM4E 2604/4885TDP1 4215/4885ALDH1A1 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.