Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620360 | 0.88 | HDAC3 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL7712193 | 0.85 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL7713143 | 0.84 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL1622235 | 0.81 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL1283866 | 0.80 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL23634757 | 0.77 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL1284909 | 0.76 | HDAC3 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL1621989 | 0.75 | HDAC3 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL1622304 | 0.75 | HDAC3 (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 | |
| SCHEMBL25816099 | 0.75 | HDAC3 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080996-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. (US) | 2010-07-15 | — | — | WO | disclosed |