⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791640 | 0.76 | MALT1 (0.31) | — | |
| SCHEMBL789708 | 0.76 | — | — | |
| SCHEMBL624468 | 0.74 | KDM4E (0.32) | — | |
| SCHEMBL789736 | 0.74 | — | — | |
| SCHEMBL3441215 | 0.71 | — | — | |
| SCHEMBL790681 | 0.69 | — | — | |
| SCHEMBL790812 | 0.69 | HSD17B10 (0.33) | — | |
| SCHEMBL790397 | 0.68 | CNR2 (0.30) | — | |
| SCHEMBL790404 | 0.67 | KDM4E (0.31) | — | |
| SCHEMBL791220 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | claimed |
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |
| WO-2005095402-A9 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2009-06-11 | — | — | WO | claimed |
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | claimed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | claimed |
| EP-1066246-B1 | NOVEL CATIONIC COUPLERS AND THEIR USE FOR OXIDATION DYEING | OREAL (FR) | 2003-11-05 | — | — | EP | claimed |
| EP-2550264-B1 | PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2016-06-08 | — | — | EP | disclosed |
| US-9040537-B2 | Pyridazine compounds for controlling invertebrate pests | BASF SE (DE) | 2015-05-26 | — | — | US | disclosed |
| EP-2615917-A2 | PYRIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS III | BASF SE (DE) | 2013-07-24 | — | — | EP | disclosed |
| US-20130180014-A1 | Pyridine Compounds for Controlling Invertebrate Pests III | BASF SE (DE) | 2013-07-11 | — | — | US | disclosed |
| EP-2550264-A1 | PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2013-01-30 | — | — | EP | disclosed |
| US-20130012380-A1 | Pyridazine Compounds For Controlling Invertebrate Pests | BASF SE (DE) | 2013-01-10 | — | — | US | disclosed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |
| WO-2003004474-A1 | PESTICIDALLY ACTIVE AMINOACETONITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-01-16 | — | — | WO | disclosed |
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |
| US-5852190-A | Diazepinoindoles as phosphodiesterase IV inhibitors | INSTITUT DE RECHERCHE JOUVEINAL SA (FR) | 1998-12-22 | — | — | US | disclosed |
| EP-0785789-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011690-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1996-04-25 | — | — | WO | disclosed |