Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 5/20 | 0.49 |
| ▸ | PLK4 | O00444 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10277917 | 0.82 | MAPT (0.49) | MAPTHTTLRRK2KDM4ERAB9A | |
| SCHEMBL1866937 | 0.81 | MAPT (0.60) | MAPTMAPK1AHRHTTIGF1R | |
| SCHEMBL27677940 | 0.76 | PDE3B (0.52) | MAPTMAPK1AHRHTTIGF1R | |
| SCHEMBL1500149 | 0.76 | SMN1; SMN2 (0.48) | MAPTMAPK1AHRHTTMEN1 | |
| SCHEMBL17631851 | 0.75 | MAPT (0.59) | MAPTMAPK1AHRHTTTP53 | |
| SCHEMBL29074152 | 0.74 | BACE1 (0.57) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL4888050 | 0.74 | MAPT (1.00) | MAPTMAPK1AHRHTTMEN1 | |
| SCHEMBL413904 | 0.73 | TTBK1 (0.55) | MAPTMAPK1IGF1RPLK4TP53 | |
| SCHEMBL5498332 | 0.72 | EGFR (0.49) | MAPTMEN1KMT2ANPSR1KDM4E | |
| SCHEMBL21848364 | 0.71 | MAPT (0.57) | MAPTMAPK1AHRHTTIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |