Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.73 |
| ▸ | PI4KA | P42356 | 7/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.66 |
| ▸ | MTOR | P42345 | 7/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.57 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.57 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.57 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807304 | 0.92 | PIK3CG (0.75) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL789793 | 0.92 | PIK3CG (0.78) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| Lithium SCHEMBL789805 | 0.91 | PIK3CG (0.77) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL789803 | 0.91 | PIK3CG (0.77) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL791474 | 0.88 | PIK3CG (0.70) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL789717 | 0.87 | PIK3CG (0.79) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL789440 | 0.87 | PIK3CG (0.75) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL790053 | 0.86 | PIK3CG (0.77) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL789337 | 0.86 | PIK3CG (0.77) | PIK3CGPI4KAPIK3CAMTORPIK3R1 | |
| SCHEMBL807240 | 0.86 | PIK3CG (0.67) | PIK3CGPI4KAPIK3CAMTORPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |