Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.55 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898672 | 1.00 | LCK (0.55) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL7887196 | 0.94 | TSHR (0.54) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL7887199 | 0.94 | TSHR (0.54) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL6932277 | 0.86 | TSHR (0.50) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL7887214 | 0.86 | TSHR (0.50) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL10929017 | 0.83 | ZDHHC7 (0.68) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL3601913 | 0.82 | TSHR (0.58) | TSHRL3MBTL1LMNAALDH1A1SLC1A1 | |
| SCHEMBL21221190 | 0.81 | LCK (0.56) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL28979205 | 0.80 | LCK (0.59) | LCKPPARDZDHHC20ZDHHC2TSHR | |
| SCHEMBL6138555 | 0.80 | TSHR (0.56) | TSHRL3MBTL1LMNAALDH1A1SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180611-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR | DARWIN DISCOVERY, LTD. (GB) | 2001-01-30 | — | — | US | disclosed |
| US-5994312-A | Peptidyl compounds | DARWIN DISCOVERY, LTD. (GB) | 1999-11-30 | — | — | US | disclosed |
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | disclosed |
| CN-1193978-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases | CHIROSCIENCE LTD (GB) | 1998-09-23 | — | — | CN | disclosed |