Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.73 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.59 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 7/20 | 0.44 |
| ▸ | RARG | P13631 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 5/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.42 |
| ▸ | RXRG | P48443 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898813 | 0.91 | CYP3A4 (0.73) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL6733878 | 0.88 | CYP3A4 (0.71) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL7900175 | 0.86 | CYP3A4 (0.69) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL6732613 | 0.85 | CYP3A4 (0.71) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL17914371 | 0.84 | CYP3A4 (1.00) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL7900451 | 0.84 | CYP3A4 (0.69) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL2788640 | 0.81 | CYP3A4 (0.70) | CYP3A4CYP26A1CYP26B1RXRARARG | |
| SCHEMBL8093197 | 0.79 | CYP3A4 (0.54) | CYP3A4CYP26A1CYP26B1MAPTLMNA | |
| SCHEMBL9187540 | 0.79 | CYP3A4 (0.76) | CYP3A4CYP26A1CYP26B1RXRARARG | |
| SCHEMBL20887627 | 0.78 | NPC1 (0.63) | MAPTLMNAGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194450-B1 | KERATINIZATION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-02-27 | — | — | US | disclosed |
| US-5849798-A | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-12-15 | — | — | US | disclosed |