Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904836 | 0.92 | PDE5A (0.49) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7893875 | 0.90 | PDE5A (0.52) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7902825 | 0.88 | PDE5A (0.48) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL8672540 | 0.87 | PDE5A (0.48) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7899640 | 0.83 | PDE5A (0.50) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7899531 | 0.80 | PDE5A (0.52) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7899538 | 0.79 | PDE5A (0.50) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7901311 | 0.79 | PDE5A (0.52) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7901292 | 0.78 | PDE5A (0.50) | PDE5AGUSBKDM4EMEN1PDE2A | |
| SCHEMBL7901289 | 0.78 | PDE5A (0.51) | PDE5AGUSBKDM4EMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187779-B1 | ADMINISTERING ANTITUMOR AGENTS TO TREAT COLON CANCER | CELL PATHWAYS, INC. | 2001-02-13 | — | — | US | disclosed |
| US-5721238-A | ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-24 | — | — | US | disclosed |
| EP-0722937-A1 | 2,8-Disubstituted quinazolinone | BAYER AG (DE) | 1996-07-24 | — | — | EP | disclosed |