Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.54 |
| ▸ | HRH2 | P25021 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902070 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7900515 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7900432 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7900325 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7902060 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7898798 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL7900342 | 1.00 | HRH4 (0.54) | HRH4HRH2HRH1SMN1; SMN2TRPV1 | |
| SCHEMBL504319 | 0.90 | HRH4 (0.59) | HRH4HRH2HRH1P2RX7 | |
| SCHEMBL504616 | 0.87 | HRH4 (0.51) | HRH4HRH2HRH1P2RX7HRH3 | |
| SCHEMBL8919055 | 0.86 | HRH4 (0.40) | HRH4HRH2NAMPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197797-B1 | ANTICANCER AGENTS; SKIN DISORDERS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-03-06 | — | — | US | claimed |
| US-6197797-B1 | ANTICANCER AGENTS; SKIN DISORDERS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-03-06 | — | — | US | disclosed |