Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30527184 | 0.75 | CYP1A2 (0.60) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL30198446 | 0.75 | CYP1A2 (0.60) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL1672650 | 0.75 | CYP1A2 (0.60) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL41506 | 0.71 | LCK (0.50) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL277638 | 0.71 | KDM4E (0.46) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL13911016 | 0.71 | CYP1A2 (0.56) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL329760 | 0.71 | KDM4E (0.46) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL3073296 | 0.71 | KDM4E (0.46) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL17871059 | 0.71 | KDM4E (0.46) | KDM4EGPR3EGFRALDH1A1MAPT | |
| SCHEMBL163312 | 0.71 | KDM4E (0.46) | KDM4EGPR3EGFRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201121-B1 | USEFUL AS ALDOSE REDUCTASE INHIBITORS, BY REACTING A DIHALO BENZYL HALIDE WITH A 1-(CARBOXYALKYL),7-HALO-2,4-QUINAZOLINEDIONE IN THE PRESENCE OF WATER CONTAINING SOLVENT; EFFICIENCY; WORKER SAFETY | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2001-03-13 | — | — | US | disclosed |
| EP-0896961-A1 | PROCESS FOR THE PREPARATION OF 3-DIHALOBENZYL-2,4-QUINAZOLINEDIONE DERIVATIVES | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-02-17 | — | — | EP | disclosed |