Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.67 |
| ▸ | PDE6D | O43924 | 10/20 | 0.53 |
| ▸ | PDE6A | P16499 | 10/20 | 0.53 |
| ▸ | PDE6G | P18545 | 10/20 | 0.53 |
| ▸ | PDE6B | P35913 | 10/20 | 0.53 |
| ▸ | PDE6C | P51160 | 10/20 | 0.53 |
| ▸ | PDE6H | Q13956 | 10/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324209 | 0.87 | PDE2A (0.74) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3325254 | 0.83 | PDE2A (0.68) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3325815 | 0.80 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL7911402 | 0.78 | PDE2A (0.48) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3323055 | 0.77 | PDE2A (0.79) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3324543 | 0.77 | PDE2A (0.79) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3325265 | 0.74 | PDE10A (0.78) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3326993 | 0.72 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3328986 | 0.71 | PDE2A (0.72) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3326795 | 0.70 | PDE2A (0.73) | PDE2APDE10APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054260-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BIOTIE THERAPIES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |