Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.65 |
| ▸ | PIK3R1 | P27986 | 13/20 | 0.65 |
| ▸ | MTOR | P42345 | 5/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | JAK1 | P23458 | 1/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902204 | 0.91 | PIK3CA (0.76) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7892233 | 0.88 | PIK3CA (0.61) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL3654994 | 0.88 | PIK3CA (0.81) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7900679 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7895054 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL14731779 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL3653208 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL8084813 | 0.84 | PIK3CA (0.54) | PIK3CAMTORKDM4EALDH1A1CYP3A4 | |
| SCHEMBL7894109 | 0.83 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7895959 | 0.83 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114494-A1 | 8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS | S*BIO PTE LTD (SG) | 2010-10-07 | — | — | WO | disclosed |