Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.62 |
| ▸ | MTOR | P42345 | 15/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786174 | 0.85 | MTOR (0.85) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3790020 | 0.85 | MTOR (0.74) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3786229 | 0.85 | MTOR (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL9948955 | 0.81 | PIK3CD (0.73) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3787800 | 0.79 | MTOR (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3785661 | 0.77 | MTOR (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL9948493 | 0.76 | MTOR (0.78) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3782675 | 0.76 | MTOR (0.78) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3786430 | 0.76 | MTOR (0.89) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3803889 | 0.75 | MTOR (0.67) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | claimed |
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2010096314-A1 | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS | AMGEN INC. (US) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | PIK3CA 9/4885MTOR 1/4885PIK3CD 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.