SCHEMBL7903472

SCHEMBL7903472

COC(=O)CCc1ccc(OCCc2nc(-c3cc4ccccc4s3)oc2C)cc1

nearest known ligand 0.55

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.55
PPARA Q07869 15/20 0.55
PPARD Q03181 6/20 0.49
FFAR1 O14842 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7909907 0.91 FFAR1 (0.59) PPARGPPARAPPARDFFAR1
SCHEMBL7903488 0.88 PPARG (0.52) PPARGPPARAPPARDFFAR1
SCHEMBL4029194 0.86 PPARG (0.56) PPARGPPARAPPARDFFAR1
SCHEMBL4026413 0.85 PPARG (0.54) PPARGPPARAPPARD
SCHEMBL7906850 0.83 PPARG (0.69) PPARGPPARAPPARDFFAR1
SCHEMBL4027344 0.82 FFAR1 (0.54) PPARGPPARAPPARDFFAR1
SCHEMBL5425749 0.82 PPARG (0.74) PPARGPPARA
SCHEMBL7897401 0.81 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL4026414 0.81 PPARA (0.61) PPARGPPARAPPARD
SCHEMBL4036937 0.80 PPARG (0.76) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6204277-B1 TREATING DIABETES JAPAN TOBACCO INC. (JP) 2001-03-20 US disclosed
EP-0930299-A1 PROPIONIC ACID DERIVATIVES AND APPLICATIONS THEREOF Japan Tobacco Inc. (JP) 1999-07-21 EP disclosed