Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467149 | 0.92 | PDE4D (0.43) | PDE4DFBP1KMT2AMEN1RAB9A | |
| SCHEMBL8031130 | 0.89 | MAPK1 (0.42) | PDE4DKMT2AMEN1MAPK1 | |
| SCHEMBL4323934 | 0.87 | CYP1A2 (0.45) | PDE4DFBP1KMT2AMEN1RAB9A | |
| SCHEMBL11996275 | 0.87 | PDE4D (0.40) | PDE4DFBP1KMT2AMEN1RAB9A | |
| SCHEMBL3467051 | 0.87 | PDE4D (0.40) | PDE4DFBP1HCRTR1HCRTR2PDE4B | |
| SCHEMBL3791661 | 0.86 | PDE4D (0.44) | PDE4DFBP1HCRTR1HCRTR2MAPT | |
| SCHEMBL3790847 | 0.86 | PDE4D (0.68) | PDE4DFBP1KMT2AMEN1RAB9A | |
| SCHEMBL3791157 | 0.86 | PDE4D (0.45) | PDE4DFBP1KMT2AMEN1CYP1A2 | |
| SCHEMBL3785842 | 0.85 | HTT (0.41) | PDE4DSMN1; SMN2PDE4BLMNATSHR | |
| SCHEMBL3787899 | 0.85 | PDE4B (0.40) | PDE4DCYP3A4CYP2D6CYP2C19HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |