Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.50 |
| ▸ | HTR2B | P41595 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 4/20 | 0.50 |
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204372 | 1.00 | DRD1 (0.50) | DRD1HTR2BKDM4ERECQLBLM | |
| Bromide SCHEMBL10718013 | 0.99 | KDM4E (0.51) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL7325308 | 0.89 | DRD1 (0.60) | DRD1HTR2BKDM4ERECQLBLM | |
| Hydrochloric Acid SCHEMBL11269253 | 0.88 | DRD1 (0.59) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL11270427 | 0.88 | DRD1 (0.45) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL11607365 | 0.88 | DRD1 (0.47) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL11607907 | 0.88 | DRD1 (0.47) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL11607370 | 0.87 | DRD1 (0.47) | DRD1HTR2BKDM4ERECQLBLM | |
| Bromide SCHEMBL11257920 | 0.87 | DRD1 (0.48) | DRD1HTR2BKDM4ERECQLBLM | |
| SCHEMBL11238141 | 0.86 | DRD1 (0.43) | DRD1HTR2BKDM4ERECQLBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321195-A | 6-Halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-03-23 | — | — | US | claimed |
| CN-120025295-A | Difluoromethyl and amino substituted olefin compound and synthesis method thereof | 浙江师范大学 | 2025-05-23 | — | — | CN | disclosed |
| EP-1082289-A4 | METHODS FOR IDENTIFYING NOVEL MULTIMERIC AGENTS THAT MODULATE RECEPTORS | ADVANCED MEDICINE INC (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-1082289-A1 | METHODS FOR IDENTIFYING NOVEL MULTIMERIC AGENTS THAT MODULATE RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999066944-A9 | METHODS FOR IDENTIFYING NOVEL MULTIMERIC AGENTS THAT MODULATE RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999066944-A1 | METHODS FOR IDENTIFYING NOVEL MULTIMERIC AGENTS THAT MODULATE RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-29 | — | — | WO | disclosed |
| EP-0476156-B1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | EISAI CO LTD (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5292521-A | And an organic acid or salt | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0476156-A1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | Eisai Co., Ltd. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-4782163-A | 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines | SMITHKLINE BECKMAN CORPORATION (US) | 1988-11-01 | — | — | US | disclosed |
| EP-0044709-A1 | New dopaminergic benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-01-27 | — | — | EP | disclosed |
| US-4285938-A | HYPERTENSIVE AGENTS; BACTERICIDES; ANTIDEPRESSANTS; INCREASE RENAL BLOOD FLOW | SMITHKLINE CORPORATION (US) | 1981-08-25 | — | — | US | disclosed |
| EP-0027348-A1 | 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives, a process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-04-22 | — | — | EP | disclosed |
| US-4251525-A | FOR TREATING ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| EP-0022330-A2 | Synergistic antihypertensive compositions | SMITHKLINE BECKMAN CORPORATION (US) | 1981-01-14 | — | — | EP | disclosed |
| EP-0020107-A1 | 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives, process for preparing them and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1980-12-10 | — | — | EP | disclosed |
| US-4197297-A | 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1980-04-08 | — | — | US | disclosed |
| EP-0004794-A2 | Substituted benzazepines, processes for preparing them and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-10-17 | — | — | EP | disclosed |
| US-4171359-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4160765-A | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds | SMITHKLINE CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |