SCHEMBL7904972

SCHEMBL7904972

CCN(CC)c1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(OCCOC(=O)CC[C@H](N)C(=O)NCCN)cc2)c1C#N

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 20/20 0.54
SLC6A3 Q01959 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13937951 0.91 ADORA1 (0.66) ADORA1SLC6A3
SCHEMBL15501129 0.91 ADORA1 (0.66) ADORA1SLC6A3
Hydrochloric Acid SCHEMBL15641612 0.90 ADORA1 (0.65) ADORA1SLC6A3
Hydrochloric Acid SCHEMBL15641615 0.90 ADORA1 (0.65) ADORA1SLC6A3
SCHEMBL13261044 0.86 ADORA1 (0.53) ADORA1SLC6A3
SCHEMBL7904995 0.86 ADORA1 (0.62) ADORA1SLC6A3
SCHEMBL13937448 0.84 ADORA1 (0.57) ADORA1SLC6A3
SCHEMBL13937436 0.84 ADORA1 (0.57) ADORA1SLC6A3
SCHEMBL15501125 0.84 ADORA1 (0.57) ADORA1SLC6A3
SCHEMBL15701261 0.83 ADORA1 (0.67) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2743270-B1 Alkylamino-substituted dicyanopyridines and their amino acid ester prodrugs BAYER IP GMBH (DE) 2016-12-21 EP disclosed
EP-2743270-A1 Alkylamino-substituted dicyanopyridines and their amino acid ester prodrugs Bayer Intellectual Property GmbH (DE) 2014-06-18 EP disclosed
EP-2391620-B1 ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF BAYER IP GMBH (DE) 2014-05-07 EP disclosed
WO-2010086101-A1 ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 WO disclosed