SCHEMBL7905736

SCHEMBL7905736

C[C@H]1C=C2N(C)C(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12

nearest known ligand 0.66

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 4/20 0.66
SRD5A1 P18405 4/20 0.66
SHBG P04278 3/20 0.52
CYP3A4 P08684 4/20 0.47
CYP19A1 P11511 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
OR51E2 Q9H255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7905737 1.00 SRD5A2 (0.66) SRD5A2SRD5A1SHBGCYP3A4CYP19A1
SCHEMBL8986784 1.00 SRD5A2 (0.66) SRD5A2SRD5A1SHBGCYP3A4CYP19A1
SCHEMBL8680322 0.84 SRD5A2 (0.75) SRD5A2SRD5A1
SCHEMBL7384872 0.83 SRD5A1 (0.62) SRD5A2SRD5A1SHBGCYP3A4CYP19A1
SCHEMBL8680318 0.82 SRD5A1 (0.61) SRD5A2SRD5A1SHBGCYP3A4
SCHEMBL8590259 0.81 SRD5A2 (0.68) SRD5A2SRD5A1
SCHEMBL917612 0.80 SRD5A2 (1.00) SRD5A2SRD5A1
SCHEMBL8333868 0.80 SRD5A2 (1.00) SRD5A2SRD5A1
SCHEMBL7613573 0.79 SRD5A1 (0.67) SRD5A1SHBGCYP3A4CYP19A1LMNA
SCHEMBL7613570 0.79 SRD5A1 (0.67) SRD5A1SHBGCYP3A4CYP19A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778284-A2 New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1997-06-11 EP claimed
EP-0572166-A1 New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors MERCK & CO. INC. (US) 1993-12-01 EP claimed
JP-6100587-A None JP disclosed
US-6204273-B1 TREATMENT OF ANDROGENIC SENSITIVE DISORDERS SUCH AS ACNE VULGARIS, SEBORRHEA, FEMALE HIRSUTISM, MALE PATTERN BALDNESS, AND BENIGN PROSTATIC HYPERPLASIA. MERCK & CO., INC. 2001-03-20 US disclosed
EP-0756481-B1 17$g(b)-ARYL-4-AZA-STEROID DERIVATIVES MERCK & CO INC (US) 2000-12-27 EP disclosed
US-5910497-A 16-pyrazinyl-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors MERCK & CO., INC. (US) 1999-06-08 US disclosed
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP disclosed
EP-0724592-B1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO INC (US) 1999-01-07 EP disclosed
EP-0792371-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1998-12-30 EP disclosed
EP-0756481-A4 17-g(b)-ARYL-4-AZA-STEROID DERIVATIVES MERCK & CO INC (US) 1998-11-18 EP disclosed
EP-0700291-B1 15-SUBSTITUTED 4-AZASTEROIDS MERCK & CO INC (US) 1998-09-16 EP disclosed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO disclosed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO disclosed
EP-0700291-A1 15-SUBSTITUTED 4-AZASTEROIDS MERCK & CO. INC. (US) 1996-03-13 EP disclosed
WO-1995028928-A1 17β-ARYL-4-AZA-STEROID DERIVATIVES MERCK & CO., INC. (US) 1995-11-02 WO disclosed
WO-1995011254-A1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO., INC. (US) 1995-04-27 WO disclosed
US-5359071-A Selective antagonist of testosterone 5-alpha-reductase 1 MERCK & CO., INC. (US) 1994-10-25 US disclosed
WO-1994020104-A1 15-SUBSTITUTED 4-AZASTEROIDS MERCK & CO, INC. (US) 1994-09-15 WO disclosed
JP-H06100587-A NEW 7 BETA-SUBSTITUTED-4-AZA-5-ALPHA-ANDROSTAN-3-ONE AS 5 ALPHA-REDUCTASE INHIBITOR MERCK & CO INC 1994-04-12 JP disclosed
EP-0572166-A1 New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors MERCK & CO. INC. (US) 1993-12-01 EP disclosed