Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586257 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL7914436 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7914394 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916373 | 0.79 | PDE4B (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7913406 | 0.78 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916380 | 0.76 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7371694 | 0.76 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7375481 | 0.75 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7914409 | 0.75 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7919768 | 0.73 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |