Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 4/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898752 | 0.99 | PDE9A (0.45) | PDE9APDE5APOLBMEN1KMT2A | |
| SCHEMBL470981 | 0.97 | PDE9A (0.43) | PDE9APDE5APOLBMEN1KMT2A | |
| SCHEMBL12043283 | 0.91 | PDE9A (0.38) | PDE9APDE5APOLBMEN1KMT2A | |
| SCHEMBL7904372 | 0.91 | PDE9A (0.38) | PDE9APDE5APOLBALDH1A1KDM4E | |
| SCHEMBL7905754 | 0.91 | PDE9A (0.38) | PDE9APDE5APOLBALDH1A1KDM4E | |
| SCHEMBL7911518 | 0.90 | PDE9A (0.37) | PDE9APOLBALDH1A1KDM4EHPGD | |
| SCHEMBL12043311 | 0.88 | PDE9A (0.37) | PDE9APDE5APOLBALDH1A1KDM4E | |
| SCHEMBL7908131 | 0.88 | PDE9A (0.36) | PDE9APDE5APOLBMEN1KMT2A | |
| SCHEMBL10053427 | 0.86 | PDE9A (0.40) | PDE9APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7898759 | 0.86 | PDE9A (0.34) | PDE9APOLBALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404922-B1 | QUINOXALINE COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2016-11-09 | — | — | EP | disclosed |
| EP-2404922-A1 | QUINOXALINE COMPOUNDS | Astellas Pharma Inc. (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101230-A1 | QUINOXALINE COMPOUNDS | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |