Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 11/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 3/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SPR | P35270 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12044086 | 0.91 | PDE9A (0.39) | PDE9APDE5APDE1APDE1BPDE1C | |
| SCHEMBL7908222 | 0.90 | PDE9A (0.39) | PDE9APDE5APDE1APDE1BPDE1C | |
| SCHEMBL7905991 | 0.86 | PDE9A (0.49) | PDE9APDE5A | |
| SCHEMBL7908218 | 0.86 | PDE9A (0.40) | PDE9APDE5APDE1ASPR | |
| SCHEMBL7906346 | 0.85 | PDE9A (0.39) | PDE9APDE5ASPRMEN1KMT2A | |
| SCHEMBL7896928 | 0.84 | PDE9A (0.45) | PDE9APDE5ASMN1; SMN2SPRKDM4E | |
| SCHEMBL10186206 | 0.83 | PDE9A (0.44) | PDE9APDE5ASMN1; SMN2SPRKDM4E | |
| SCHEMBL1721345 | 0.82 | PDE9A (0.47) | PDE9APDE5APDE1APDE1BPDE1C | |
| SCHEMBL7908759 | 0.81 | PDE9A (0.46) | PDE9APDE5ASPRALDH1A1HPGD | |
| SCHEMBL7900336 | 0.81 | PDE9A (0.42) | PDE9APDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404922-A1 | QUINOXALINE COMPOUNDS | Astellas Pharma Inc. (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101230-A1 | QUINOXALINE COMPOUNDS | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |