Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14315137 | 0.89 | KMT2A (0.46) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL518693 | 0.88 | KMT2A (0.66) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519036 | 0.88 | POLB (0.60) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL518692 | 0.88 | KMT2A (0.66) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519035 | 0.88 | POLB (0.60) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519061 | 0.88 | KMT2A (0.50) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519060 | 0.88 | KMT2A (0.50) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519706 | 0.87 | KMT2A (0.49) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL519707 | 0.87 | KMT2A (0.49) | KMT2AMEN1POLBCYP2C9GAA | |
| SCHEMBL2497675 | 0.87 | MEN1 (0.49) | KMT2AMEN1POLBCYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |