Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.85 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14578975 | 0.92 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364913 | 0.90 | PDE4A (0.87) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8925092 | 0.89 | PDE4A (0.85) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7908753 | 0.89 | PDE4A (0.85) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL1389110 | 0.87 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL84490 | 0.87 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL29412448 | 0.87 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL153739 | 0.87 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL29351573 | 0.87 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| Cdp840 SCHEMBL16654879 | 0.86 | PDE4D (1.00) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |