Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 19/20 | 0.74 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910405 | 0.90 | MAP3K11 (0.62) | MAP3K11LRRK2 | |
| SCHEMBL7908179 | 0.86 | MAP3K11 (0.54) | MAP3K11LRRK2 | |
| SCHEMBL18197630 | 0.85 | MAP3K11 (1.00) | MAP3K11LRRK2 | |
| SCHEMBL17226856 | 0.84 | MAP3K11 (0.52) | MAP3K11LRRK2 | |
| SCHEMBL7904021 | 0.84 | MAP3K11 (0.52) | MAP3K11LRRK2 | |
| SCHEMBL7911755 | 0.84 | MAP3K11 (0.66) | MAP3K11 | |
| SCHEMBL7907776 | 0.83 | MAP3K11 (0.68) | MAP3K11LRRK2FYN | |
| SCHEMBL7910380 | 0.82 | MAP3K11 (0.62) | MAP3K11 | |
| SCHEMBL7897792 | 0.82 | MAP3K11 (0.74) | MAP3K11LRRK2 | |
| SCHEMBL722624 | 0.82 | MAP3K11 (1.00) | MAP3K11LRRK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |