SCHEMBL7907854

SCHEMBL7907854

CCCCC[C@H]1CC[C@H](c2cc(F)c(-c3ccc(OC(F)(F)F)cc3)c(F)c2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.37
KDM1A O60341 1/20 0.34
RCOR1 Q9UKL0 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
MMP12 P39900 2/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM5 P08912 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
GRIN2B Q13224 1/20 0.33
PDE2A O00408 1/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7907856 1.00 SCN9A (0.37) SCN9AKDM1ARCOR1GAAMAPT
SCHEMBL16579162 0.97 SCN9A (0.36) SCN9AKDM1ARCOR1MMP12HDAC3
SCHEMBL16579012 0.92 CYP2C9 (0.38) KDM1ARCOR1MAPTMMP12MEN1
SCHEMBL3168351 0.91 TRPV1 (0.34) SCN9AGAAMAPTMEN1KMT2A
SCHEMBL3168341 0.91 TRPV1 (0.34) SCN9AGAAMAPTMEN1KMT2A
SCHEMBL6454961 0.91 SCN9A (0.34) SCN9AKDM1ARCOR1GAAMAPT
SCHEMBL6454957 0.91 SCN9A (0.34) SCN9AKDM1ARCOR1GAAMAPT
SCHEMBL8768436 0.91 KCNQ3 (0.38) MMP12CHRM2CHRM5CHRM1CHRM3
SCHEMBL8768428 0.91 KCNQ3 (0.38) MMP12CHRM2CHRM5CHRM1CHRM3
SCHEMBL6455550 0.90 SCN9A (0.33) SCN9AKDM1ARCOR1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326066-B1 CHEMICAL STABILITY, LOW VISCOSITY, HIGH DIELECTRIC ANISOTROPY, ULTRAVIOLET AND TEMPERATURE STABILITY; USED IN ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT RESCHANKTER HAFTUNG (DE) 2001-12-04 US disclosed
US-6200654-B1 ELECTROOPTIC DISPLAYING MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2001-03-13 US disclosed
EP-0721933-B1 1,4-Disubstituted 2,6-difluorobenzene compounds and liquid crystal media MERCK PATENT GMBH (DE) 1999-07-07 EP disclosed
EP-0462237-B1 1,2-DISUBSTITUTED 2,6-DIFLUOROBENZENE COMPOUNDS AND LIQUID CRYSTAL MEDIA MERCK PATENT GMBH (DE) 1997-03-12 EP disclosed
EP-0721933-A1 1,4-Disubstituted 2,6-difluorobenzene compounds and liquid crystal media MERCK PATENT GmbH (DE) 1996-07-17 EP disclosed
EP-0462237-A1 1,2-DISUBSTITUTED 2,6-DIFLUOROBENZENE COMPOUNDS AND LIQUID CRYSTAL MEDIA. MERCK PATENT GMBH (DE) 1991-12-27 EP disclosed
WO-1991008184-A2 1,2-DISUBSTITUTED 2,6-DIFLUOROBENZENE COMPOUNDS AND LIQUID CRYSTAL MEDIA MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-06-13 WO disclosed