Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 10/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 10/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476512 | 0.88 | CYP2C19 (0.43) | TP53MDM2ALDH1A1CNR1 | |
| SCHEMBL476314 | 0.88 | CNR1 (0.51) | CNR1 | |
| SCHEMBL476392 | 0.84 | CNR1 (0.43) | TP53MDM2CNR1 | |
| SCHEMBL476369 | 0.78 | SRD5A2 (0.45) | TP53MDM2ALDH1A1CNR1 | |
| SCHEMBL16175059 | 0.78 | CNR1 (0.53) | ALDH1A1CNR1 | |
| SCHEMBL476367 | 0.78 | CNR1 (0.47) | TP53MDM2CNR1 | |
| SCHEMBL2682560 | 0.77 | TP53 (0.48) | TP53MDM2ALDH1A1NPSR1CNR1 | |
| SCHEMBL476186 | 0.77 | CNR1 (0.51) | TP53MDM2CNR1 | |
| SCHEMBL2682102 | 0.76 | CNR1 (0.50) | ALDH1A1NPSR1CNR1 | |
| SCHEMBL476254 | 0.76 | CNR1 (0.46) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |