Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908462 | 1.00 | HCRTR2 (0.44) | HCRTR2ATMHSD17B10PDE8BSMN1; SMN2 | |
| SCHEMBL13567964 | 0.89 | HCRTR2 (0.43) | HCRTR2ATMHSD17B10PDE8BSMN1; SMN2 | |
| SCHEMBL2261445 | 0.88 | HCRTR2 (0.42) | HCRTR2ATMHSD17B10PDE8BSMN1; SMN2 | |
| SCHEMBL2465396 | 0.87 | HSD17B10 (0.54) | HCRTR2HSD17B10PDE8BSMN1; SMN2ALOX5AP | |
| SCHEMBL30785490 | 0.87 | PDE8B (0.41) | HCRTR2ATMHSD17B10PDE8BSMN1; SMN2 | |
| SCHEMBL30785417 | 0.86 | HSD17B10 (0.42) | HCRTR2ATMHSD17B10PDE8BEPHX1 | |
| SCHEMBL2432658 | 0.85 | HCRTR2 (0.45) | HCRTR2HSD17B10PDE8BSMN1; SMN2ALOX5AP | |
| SCHEMBL2429382 | 0.85 | HCRTR2 (0.45) | HCRTR2HSD17B10PDE8BSMN1; SMN2ALOX5AP | |
| SCHEMBL2431740 | 0.85 | HCRTR2 (0.45) | HCRTR2HSD17B10PDE8BSMN1; SMN2ALOX5AP | |
| SCHEMBL5151768 | 0.85 | HCRTR2 (0.45) | HCRTR2HSD17B10PDE8BSMN1; SMN2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346982-B1 | VLA-4 INHIBITORS | DAIICHI SEIYAKU CO (JP) | 2011-09-14 | — | — | EP | disclosed |
| US-6277871-B1 | ANTICANCER AGENTS | ABBOTT LABORATORIES | 2001-08-21 | — | — | US | disclosed |
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |