Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 13/20 | 0.37 |
| ▸ | CDK2 | P24941 | 13/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.37 |
| ▸ | AURKA | O14965 | 8/20 | 0.37 |
| ▸ | PLK1 | P53350 | 5/20 | 0.37 |
| ▸ | TTK | P33981 | 7/20 | 0.36 |
| ▸ | CDK4 | P11802 | 4/20 | 0.36 |
| ▸ | CCND3 | P30281 | 4/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.36 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911087 | 0.87 | CDK2 (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL2548366 | 0.79 | CDK2 (0.57) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL7903264 | 0.74 | GRM5 (0.63) | — | |
| SCHEMBL7913600 | 0.72 | TDP1 (0.47) | TTKCHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL2540871 | 0.71 | CCNA2 (0.60) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL4912110 | 0.68 | TSHR (0.43) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL2186516 | 0.67 | CDK2 (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL10044909 | 0.67 | PTAFR (0.39) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL2548991 | 0.66 | AURKA (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL2550010 | 0.65 | CDK2 (0.43) | CCNA2CDK2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |