Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.68 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519221 | 0.90 | PDE10A (0.82) | PDE10AALDH1A1HTTNPSR1 | |
| SCHEMBL2751153 | 0.90 | PDE10A (0.69) | PDE10ANPBWR1MCHR1ALDH1A1MAPT | |
| SCHEMBL2499075 | 0.90 | PDE10A (0.69) | PDE10ANPBWR1MCHR1ALDH1A1HTT | |
| SCHEMBL7909376 | 0.90 | PDE10A (0.85) | PDE10AALDH1A1CYP2C9NPSR1 | |
| Hydrogen Sulfide SCHEMBL27843272 | 0.89 | PDE10A (0.81) | PDE10AALDH1A1HTTNPSR1 | |
| SCHEMBL2751859 | 0.88 | PDE10A (0.63) | PDE10A | |
| SCHEMBL2749193 | 0.87 | PDE10A (0.64) | PDE10ANPBWR1MCHR1ALDH1A1SCN5A | |
| SCHEMBL2749131 | 0.86 | PDE10A (0.83) | PDE10AALDH1A1NPSR1 | |
| SCHEMBL2499083 | 0.86 | PDE10A (0.63) | PDE10A | |
| SCHEMBL2750815 | 0.85 | PDE10A (0.67) | PDE10AALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | disclosed |
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |