SCHEMBL7909689

SCHEMBL7909689

Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2OC(=O)NC2=O)cc1

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.63
PPARA Q07869 15/20 0.63
CYP3A4 P08684 1/20 0.58
CYP2C9 P11712 1/20 0.58
KCNH2 Q12809 1/20 0.58
PPARD Q03181 5/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9098920 0.91 PPARG (0.57) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL7164855 0.91 PPARG (0.62) PPARGPPARAPPARD
SCHEMBL9097885 0.91 PPARG (0.53) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL7162959 0.89 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL7162075 0.88 PPARG (0.58) PPARGPPARAPPARD
SCHEMBL9097890 0.86 PPARG (0.50) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL9094305 0.86 PPARG (0.59) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL9097431 0.85 PPARG (0.48) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL7487592 0.84 PPARG (0.47) PPARGPPARACYP3A4CYP2C9KCNH2
SCHEMBL8795234 0.84 FFAR1 (0.62) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6204277-B1 TREATING DIABETES JAPAN TOBACCO INC. (JP) 2001-03-20 US disclosed
US-6160124-A Method for treating or preventing arteriosclerosis JAPAN TOBACCO INC. (JP) 2000-12-12 US disclosed
US-6057343-A HAVE SUPERIOR HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIONS AND ARE USEFUL FOR THE TREATMENT OF DIABETES AND THE COMPLICATIONS THEREOF, AS WELL AS THERAPEUTIC AGENTS FOR RELATED DISEASES SUCH AS HYPERLIPIDEMIA JAPAN TOBACCO, INC. (JP) 2000-05-02 US disclosed
US-6037359-A ARTERIOSCLEROSIS PREVENTION; ANTIDIABETIC AGENTS; ANTILIPEMIC AND HYPOGLYCEMIC AGENTS JAPAN TOBACCO, INC. (JP) 2000-03-14 US disclosed
EP-0930299-A1 PROPIONIC ACID DERIVATIVES AND APPLICATIONS THEREOF Japan Tobacco Inc. (JP) 1999-07-21 EP disclosed
EP-0684242-B1 ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF JAPAN TOBACCO INC (JP) 1999-05-06 EP disclosed
US-5498621-A Oxazolidinedione hypoglycemic agents PFIZER INC. (US) 1996-03-12 US disclosed
EP-0684242-A1 ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF JAPAN TOBACCO INC. (JP) 1995-11-29 EP disclosed
EP-0428312-B1 Oxazolidinedione hypoglycemic agents PFIZER (US) 1994-12-28 EP disclosed
WO-1991007107-A1 OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1991-05-30 WO disclosed
EP-0428312-A2 Oxazolidinedione hypoglycemic agents PFIZER INC. (US) 1991-05-22 EP disclosed