Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | HPGD | P15428 | 7/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | CA12 | O43570 | 3/20 | 0.71 |
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA9 | Q16790 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29417934 | 1.00 | KDM4E (0.73) | KDM4EALDH1A1HPGDGAAGLA | |
| Hydrochloric Acid SCHEMBL29398718 | 0.99 | KDM4E (0.71) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL4005910 | 0.91 | KDM4E (0.65) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL29449376 | 0.91 | KDM4E (0.65) | KDM4EALDH1A1HPGDGAAGLA | |
| Hydrochloric Acid SCHEMBL29692734 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL5675501 | 0.90 | KDM4E (0.77) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL12986344 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL11231059 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL29435302 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL29435304 | 0.86 | KDM4E (0.81) | KDM4EALDH1A1HPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5255388-A | — | — | None | — | — | JP | disclosed |
| US-20130267680-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | STICHTING HET NEDERLANDS KANKERINSTITUUT | 2013-10-10 | — | — | US | disclosed |
| EP-2616479-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | Stichting Het Nederlands Kanker Instituut (NL) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012036551-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | STICHTING HET NEDERLANDS KANKERINSTITUUT (NL) | 2012-03-22 | — | — | WO | disclosed |
| US-6348570-B1 | TETRAPEPTIDES; DIAGNOSING AND MONITORING INFLAMMATORY, NERVOUS SYSTEM, SKIN, CARDIOVASCULAR, RESPIRATORY SYSTEM, GASTROINTESTINAL, UROGENITAL AND IMMUNE DISORDERS; EVALUATING INHIBITORS | MERCK & CO., INC. | 2002-02-19 | — | — | US | disclosed |
| JP-H05255388-A | NEW CHROMOPHORE-CONTAINING COMPOUND AND METHOD FOR USING IT IN DETERMINING INTERLEUKIN-1BETA CONVERTASE ACTIVITY | MERCK & CO INC | 1993-10-05 | — | — | JP | disclosed |
| EP-0533226-A2 | Novel chromophore containing compounds | MERCK & CO. INC. (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0528487-A2 | Novel chromophore containing compounds | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267680-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | UBQLN1, UBQLN2, UBE3A | KDM4E 964/4885ALDH1A1 2827/4885HPGD 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.