SCHEMBL7910883

SCHEMBL7910883

O=C(NCCO)c1ccc(OCc2ccsc2)cc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
CASP1 P29466 1/20 0.47
CASP7 P55210 1/20 0.47
SPHK2 Q9NRA0 1/20 0.46
SPHK1 Q9NYA1 1/20 0.46
PARP15 Q460N3 1/20 0.45
PARP10 Q53GL7 1/20 0.45
PARP3 Q9Y6F1 1/20 0.45
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAOB P27338 4/20 0.42
MMP1 P03956 1/20 0.41
MMP9 P14780 1/20 0.41
MMP13 P45452 1/20 0.41
ADAM17 P78536 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7901116 0.87 PARP15 (0.43) PARP15PARP10PARP3MEN1NPC1
SCHEMBL7900825 0.86 GUSB (0.43) PARP15PARP10PARP3MEN1NPC1
SCHEMBL7910690 0.84 PARP15 (0.44) ALDH1A1PARP15PARP10PARP3MAOB
SCHEMBL7900989 0.84 PARP15 (0.44) MAPTPARP15PARP10PARP3MAOB
SCHEMBL7908116 0.80 CA12 (0.51) PARP15PARP10PARP3NPC1MAOB
SCHEMBL7900858 0.80 PARP15 (0.51) PARP15PARP10PARP3MAOBMAOA
SCHEMBL7914316 0.80 MAOB (0.66) ALDH1A1MAPTPARP15PARP10PARP3
SCHEMBL7901133 0.79 SMN1; SMN2 (0.49) KDM4EALDH1A1MAPTMEN1NPC1
SCHEMBL7907977 0.77 PARP15 (0.48) MAPTPARP15PARP10PARP3MAOB
SCHEMBL7901210 0.76 PARP15 (0.45) PARP15PARP10PARP3MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed