Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822025 | 0.86 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7908615 | 0.85 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6885590 | 0.83 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL14578975 | 0.83 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7914518 | 0.83 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364296 | 0.82 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4822203 | 0.81 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6888806 | 0.81 | PDE4A (0.68) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8357145 | 0.81 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4816554 | 0.81 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |